BDBM50225106 (2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid::(2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid]]::(2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoic acid::(2S)-2-amino-5-{[imino(nitroamino)methyl]amino}pentanoic acid::(S)-2-Amino-5-(N'-nitro-guanidino)-pentanoic acid::2-Amino-5-(N'-nitro-guanidino)-pentanoic acid::CHEMBL227744::N-OMEGA-NITRO-L-ARGININE::N-nitro-L-arginine::NG-nitroarginine::Ngamma-nitro-L-arginine::Nomega-nitro-L-arginine

SMILES N[C@@H](CCCNC(N)=N[N+]([O-])=O)C(O)=O

InChI Key InChIKey=MRAUNPAHJZDYCK-BYPYZUCNSA-N

Data  10 KI  26 IC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50225106   

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  500nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  570nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  610nM ΔG°:  -8.61kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  670nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  720nM ΔG°:  -8.51kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  750nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  4.28E+3nM ΔG°:  -7.44kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  4.55E+3nMAssay Description:Inhibition of rat recombinant nNOSMore data for this Ligand-Target Pair