BDBM25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720
SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F
InChI Key InChIKey=YZDJQTHVDDOVHR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 25617
Affinity DataIC50: 160nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERKMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of B-Raf in presence of 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataKd: 330nMAssay Description:Binding constant for BRAF kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) by lantha screen assayMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for BRAF(V600E) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human full length GST-tagged BRAF expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of wild type B-Raf (unknown origin) by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) by Alphascreen assayMore data for this Ligand-Target Pair