BDBM2583 3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione::3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::BIM-4::Bisindolyl deriv. 3::Bisindolylmaleimide deriv. 5::CHEMBL266487::bis-indolylmaleimide deriv. 8a
SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
InChI Key InChIKey=DQYBRTASHMYDJG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 2583
Affinity DataIC50: 550nMpH: 7.5 T: 30°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Human)
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 7.4 T: 30°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMpH: 7.0 T: 30°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
TargetPhosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform(Rabbit)
Laboratoires Glaxo
Laboratoires Glaxo
Affinity DataIC50: 3.20E+3nMpH: 7.0 T: 30°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: 5.81E+3nMpH: 7.0 T: 22°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Affinity DataIC50: 1.17E+4nMT: 25°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMT: 25°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibitory activity was determined against protein kinase A (PKA) of rabbitMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against v-abl tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataKd: 27nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Human)
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 212nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C beta 2More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C alphaMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Albert-Ludwigs-University of Freiburg
Curated by ChEMBL
Albert-Ludwigs-University of Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Human)
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 304nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C beta 1More data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Human)
Central Pharmaceutical Research Institute
Curated by ChEMBL
Central Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 7.52E+3nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C epsilonMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Human)
Scios
Curated by ChEMBL
Scios
Curated by ChEMBL
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of CaMK2deltaMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Human)
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory concentration was determined by measuring phoshporylation of H1 histone using active human Cell division cycle 2-cyclin B complexMore data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+4nMpH: 8.5 T: 37°CAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 2583
ITC DataΔG°: -9.78kcal/mole −TΔS°: 0.548kcal/mole ΔH°: -10.4kcal/mole logk: 3.70E+7
pH: 7.5 T: 10.00°C
pH: 7.5 T: 10.00°C