BDBM35318 aminoisoquinoline, 12a

SMILES Cc1ccc2c(Nc3cccc(c3)C(F)(F)F)nccc2c1Nc1ncccc1-c1ccncn1

InChI Key InChIKey=CCUWZTRFTGLQCV-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 35318   

LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50:  17nM EC50:  53nMpH: 7.0 T: 23°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50: >1.60E+3nMpH: 7.5 T: 23°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50:  47nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50:  81nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35318(aminoisoquinoline, 12a)
Affinity DataIC50:  760nMpH: 7.5 T: 23°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed