BDBM50121975 (6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol::CARDIOQUIN::CHEMBL1294::CIN-QUIN::DURAQUIN::QUINACT::QUINAGLUTE::QUINALAN::QUINATIME::QUINIDEX::QUINIDINE::QUINORA::US9402878, Quinidine
SMILES COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
InChI Key InChIKey=LOUPRKONTZGTKE-LHHVKLHASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 50121975
Affinity DataKi: 9.80nMAssay Description:Inhibition of human CYP2D6 by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity for cytochrome P450 2D6More data for this Ligand-Target Pair
Affinity DataIC50: <6nMAssay Description:Inhibition of CYP2D6 in human liver microsomeMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP2D6 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant CYP2D6 using MFC as substrate incubated for 40 mins by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human CYP2D6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant microsomal CYP2D6 using {3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin} as substrate assessed as ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human CYP2D6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human CYP2D6 by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of human liver microsome CYP2D6 in assessed as [14C]formaldehyde formationMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant CYP2D6 expressed in insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant CYP2D6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant CYP2D6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human CYP2D6 expressed in baculovirus-infected insect cell systemMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2D6 in pooled human hepatic microsomes using dextromethorphan substrate in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate upto 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 118nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2D6 (unknown origin) using AMMC by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 263nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 20 mins in presence of NADP by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan substrate incubated for 10 mins in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes pre-incubated for 5 mins before NADPH addition and measured after 10 mins by UPLC-MS/MS analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan substrate in presence of NADPH incubated for 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant CYP2D6 using luciferin as substrate preincubated for 10 mins followed by substrate addition and measured after 50 min...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6 in presence of NADPH by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human CYP2D6 in presence of NADPH by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CYP2D6 (unknown origin) expressed in insect cell microsomes using dibenzylfluorescein substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of CYP2D6 in human liver microsome using probe substrate measured after 20 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+3nMAssay Description:Inhibition of human CYP2D6 using dextromethorphan as substrate in presence of NADPH incubated for 15 to 45 minsMore data for this Ligand-Target Pair