BDBM50248629 CHEMBL4076837::US11471446, Compound DBA-9
SMILES CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ncnc4ccc(cc34)C#N)ccc2c1
InChI Key InChIKey=VNADJTWHOAMTLY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50248629
Affinity DataIC50: 24nMAssay Description:Inhibition of full length N-terminal GST/His6-tagged human CDK8 (M1 to Y463 residues)/N-terminal His6-tagged Cyc C (M1 to S283 residues) expressed in...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of kinase tracer 236 binding to His tagged recombinant human CDK8/cyclin C incubated for 60 min FRET based LanthaScreen Eu-Kinase binding ...More data for this Ligand-Target Pair
Affinity DataKd: 2nMAssay Description:Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Binding affinity to recombinant human CDK19/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair