BDBM50658381 ACLONIFEN

SMILES c1ccc(cc1)Oc2ccc(c(c2Cl)N)[N+](=O)[O-]

InChI Key InChIKey=DDBMQDADIHOWIC-UHFFFAOYSA-N

Data  1 KI  2 Kd

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50658381   

TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658381BDBM50658381(ACLONIFEN)
Affinity DataKd:  184nMAssay Description:Binding affinity to wildtype TTR (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658381BDBM50658381(ACLONIFEN)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of acid-mediated TTR V30M mutant (unknown origin) aggregation preincubated for 30 mins followed by sodium acetate buffer at pH 5.2 additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658381BDBM50658381(ACLONIFEN)
Affinity DataKd:  5.80E+4nMAssay Description:Binding affinity to human thyroid hormone-beta receptor assessed as apparent dissociation constant by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed