BDBM50590927 APILIMOD::Apilimod::STA 5326::STA-5326::Sta-5326::US20240016810, Compound TABLE 16.1

SMILES Cc1cccc(\C=N\Nc2cc(nc(OCCc3ccccn3)n2)N2CCOCC2)c1

InChI Key InChIKey=HSKAZIJJKRAJAV-KOEQRZSOSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50590927   

Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human GST tagged PIKFYVE (1493 to end residues) expressed in baculovirus-infected Sf9 cells using PI(3)P:PS as substrate incubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  0.312nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  0.309nMAssay Description:Inhibition of PIKFYVE in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  3nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human PIKfyve in HEK293 lysate using di-C8 PI(3)P as substrate preincubated for 5 mins followed by substrate addition measured after 2 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PIKfyve (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PIKFYVE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50590927(APILIMOD | Apilimod | STA 5326 | STA-5326 | Sta-53...)
Affinity DataKd:  0.0750nMAssay Description:Binding affinity to human wild type partial length PIKFYVE (F1512 to C2098 residues) mammalian expression assessed as dissociation constant by Kinome...More data for this Ligand-Target Pair
In DepthDetails PubMed