BDBM50623923 ARV-471::ARV471::Arv 471::VEPDEGESTRANT::Vepdegestrant

SMILES Oc1ccc2[C@H]([C@H](CCc2c1)c1ccccc1)c1ccc(cc1)N1CCC(CN2CCN(CC2)c2ccc3C(=O)N(Cc3c2)[C@H]2CCC(=O)NC2=O)CC1

InChI Key InChIKey=TZZDVPMABRWKIZ-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50623923   

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623923BDBM50623923(Vepdegestrant | Arv 471 | ARV-471 | ARV471 | VEPDE...)
Affinity DataEC50:  1nMAssay Description:Induction of ERalpha degradation in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoChEBI
Similars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623923BDBM50623923(Vepdegestrant | Arv 471 | ARV-471 | ARV471 | VEPDE...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of NKG2D (unknown origin)/MICA (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoChEBI
Similars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623923BDBM50623923(Vepdegestrant | Arv 471 | ARV-471 | ARV471 | VEPDE...)
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at Gal4-fused ER-alpha (unknown origin) expressed in HEK293 cells assessed as inhibition of estradiol-induced ERE luciferase gene...More data for this Ligand-Target Pair
Ligand InfoChEBI
Similars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed