BDBM50585017 AZD6738::Atr kinase inhibitor azd6738::Azd 6738::Azd-6738::CERALASERTIB::Ceralasertib
SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cc[nH]c2nccc12)C1(CC1)[S@](C)(=N)=O
InChI Key InChIKey=OHUHVTCQTUDPIJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50585017
Affinity DataKi: 0.0600nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant full length ATR using GST-cMyc-p53 as substrate incubated for 40 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
Affinity DataKd: 175nMAssay Description:Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by q-PCR bas...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Affinity DataKd: 427nMAssay Description:Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) by Alphascreen assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.67E+3nMAssay Description:Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan...More data for this Ligand-Target Pair
Affinity DataKd: 1.69E+3nMAssay Description:Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human full length recombinant mTOR measured after 40 mins in presence of [gamma-33P]ATP by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Human)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human full length recombinant DNA-PK using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length recombinant ATM using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISAMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Repare Therapeutics, Inc.
Curated by ChEMBL
Repare Therapeutics, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K alpha (unknown origin) by kinase profiler analysisMore data for this Ligand-Target Pair