BDBM50635713 AZD9574::Azd-9574::US20250346573, Compound AZD9574
SMILES CC1=Nc2ccc(c(c2NC1=O)F)CN3CCN(CC3)c4ccc(nc4F)C(=O)NC
InChI Key InChIKey=WXRCLFFPZXJCLS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50635713
Affinity DataKd: 0.540nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.602nMAssay Description:1. Test PurposeThis test is used to evaluate the effect of the test compounds on the PARP1 and PARP2 enzyme activities, and the IC50 value of the tes...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP1 in PARP2 knockout human A549 cells preincubated with compound for 1 hr followed by H2O2 addition and measured after 5 mins by sel...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albuminMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of PARP1 (unknown origin) expressed in Escherichia coli BL21 incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of PARP1 in wild type human A549 cells preincubated with compound for 1 hr followed by H2O2 addition and measured after 5 mins by PARylati...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: 153nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Affinity DataEC50: 297nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Affinity DataIC50: 870nMAssay Description:Agonist activity at OX2R (unknown origin) expressed in CHO cells by cell based calcium assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PARP2 in PARP1 knockout human A549 cells preincubated with compound for 1 hr followed by H2O2 addition and measured after 5 mins by sel...More data for this Ligand-Target Pair
Affinity DataIC50: 3.48E+3nMAssay Description:1. Test PurposeThis test is used to evaluate the effect of the test compounds on the PARP1 and PARP2 enzyme activities, and the IC50 value of the tes...More data for this Ligand-Target Pair
Affinity DataEC50: 7.26E+3nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of TEL-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.72E+5nMAssay Description:Inhibition of GSK-3beta (unknown origin) assessed as decrease in tau phosphorylation by high content cell based assayMore data for this Ligand-Target Pair