BDBM50366597 2-Acetylfuranonaphthoquinone::BBI-608::Napabucasin

SMILES CC(=O)c1cc2c(o1)C(=O)c1ccccc1C2=O

InChI Key InChIKey=DPHUWDIXHNQOSY-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50366597   

TargetAldehyde dehydrogenase 1A1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: 425nMAssay Description:Inhibition of ALDH1A1 in human drug-tolerant MDA-MB-231/lapatinib cells assessed as after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation at Tyr705 residue in human MCF7 cells preincubated for 1 hr followed by IL-6 stimulation and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of leukemia inhibitory factor-induced STAT3 transcriptional activity in human HeLa cells expressing 4SIE pretreated for 1 hr followed by L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of IL-6-induced STAT3 activation in HEK293-STAT3-Luc2P cell line assessed as decrease in phosphorylated STAT3 (p-STAT3 Tyr705) level measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells assessed as reduction in ratio of phosphorylated STAT3 to total STAT3 level aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of STAT3 phosphorylation at Y705 in human MDA-MB-231 cells after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK293 cells expressing SIE-luc2P preincubated for overnight followed by IL-6 stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50366597(2-Acetylfuranonaphthoquinone | BBI-608 | Napabucas...)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to recombinant His-tagged STAT3 (127 to 722 residues) (unknown origin) expressed in Escherichia coli BL-21 Star (De3) pLysS by bio-l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed