BDBM100205 MLS000561583::N-[5-[2-(5-chloro-2-methoxy-anilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]-2,2-dimethyl-propionamide::N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide::N-[5-[2-(5-chloro-2-methoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]-2,2-dimethylpropanamide::N-[5-[2-[(5-chloranyl-2-methoxy-phenyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethyl-propanamide::SMR000156108::cid_11958611

SMILES COc1ccc(Cl)cc1Nc1nc(cs1)-c1sc(NC(=O)C(C)(C)C)nc1C

InChI Key InChIKey=XERLNCVIGMCAMO-UHFFFAOYSA-N

Data  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 100205   

TargetCystic fibrosis transmembrane conductance regulator(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100205BDBM100205(cid_11958611 | N-[5-[2-(5-chloro-2-methoxyanilino)...)
Affinity DataKd:  700nMAssay Description:Corrector activity at human CFTR deltaF508 mutant expressed in FRT cells assessed as iodide influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100205BDBM100205(cid_11958611 | N-[5-[2-(5-chloro-2-methoxyanilino)...)
Affinity DataEC50:  700nMAssay Description:Binding affinity to human CFTR F508 deletion mutant expressed in FRT cells assessed as increase in iodine influx after 16 to 20 hrs by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100205BDBM100205(cid_11958611 | N-[5-[2-(5-chloro-2-methoxyanilino)...)
Affinity DataEC50:  708nMAssay Description:Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
University of California

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100205BDBM100205(cid_11958611 | N-[5-[2-(5-chloro-2-methoxyanilino)...)
Affinity DataEC50:  870nMAssay Description:Activity of human CFTR F508 deletion mutant expressed in FRT cells assessed as potentiation of genistein-induced iodine ion influx after 24 hrs by YF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed