BDBM10237 6-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydro-1H-1,3-benzodiazol-2-one::benzimidazol-2-one 1

SMILES Fc1cccc(F)c1Cn1c2cc(Cl)ccc2[nH]c1=O

InChI Key InChIKey=YMOMBCSJYZNOLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10237   

TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM10237(6-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 700nMAssay Description:Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Messina

Curated by ChEMBL
LigandPNGBDBM10237(6-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 700nMAssay Description:Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as incorporation of radioactive dTTP into poly(rA)/oligo(DT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Universita Di Messina

LigandPNGBDBM10237(6-chloro-1-[(2,6-difluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 2.86E+3nMpH: 7.5 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2006
Entry Details Article
PubMed