BDBM103504 CHEMBL2172192::US8552017, 2(7).HCl

SMILES CNc1nn2cc3CN(C)CCc3nc2c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=CHVVPMVMKPMDFR-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 103504   

Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM103504(CHEMBL2172192 | US8552017, 2(7).HCl)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM103504(CHEMBL2172192 | US8552017, 2(7).HCl)
Affinity DataKi:  3.26nM IC50: 7.02nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM103504(CHEMBL2172192 | US8552017, 2(7).HCl)
Affinity DataKi:  14.3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HE293 cells assessed as inhibition of serotonin-induced cAMP accumulation after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM103504(CHEMBL2172192 | US8552017, 2(7).HCl)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant ERG channel expressed in HEK297 cells after 3 to 8 mins by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed