BDBM103946 CHEMBL2172189::US8569318, 2.2(2)

SMILES CSc1nn2cc3CN(C)CCc3nc2c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=XYJSJXVLOQQHSH-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103946   

Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM103946(CHEMBL2172189 | US8569318, 2.2(2))
Affinity DataKi:  372nM IC50: 801nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM103946(CHEMBL2172189 | US8569318, 2.2(2))
Affinity DataKi:  372nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in HeLa cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
TBA

US Patent
LigandPNGBDBM103946(CHEMBL2172189 | US8569318, 2.2(2))
Affinity DataKi:  492nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HE293 cells assessed as inhibition of serotonin-induced cAMP accumulation after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed