BDBM105075 CHEMBL2152708::US8569281, 59

SMILES CC(C)Oc1nccc2[nH]nc(-c3cc(C(=O)NC4COC4)n(c3)C(C)C)c12

InChI Key InChIKey=KROJTAOUSJBQLC-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 105075   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Medical Research Council Technology

US Patent
LigandPNGBDBM105075(CHEMBL2152708 | US8569281, 59)
Affinity DataKi:  2.40nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Medical Research Council Technology

US Patent
LigandPNGBDBM105075(CHEMBL2152708 | US8569281, 59)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Medical Research Council Technology

US Patent
LigandPNGBDBM105075(CHEMBL2152708 | US8569281, 59)
Affinity DataKi:  2.40nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed