BDBM106157 US9695174, 8

SMILES COc1cc2[nH]c3[C@H](CC(C)C)N4[C@@H](Cc3c2cc1OC)C(=O)N[C@@H](C)C4=O

InChI Key InChIKey=TUPQWFMUKKBKJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106157   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106157(US9695174, 8)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106157(US9695174, 8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106157(US9695174, 8)
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:To determine potency of compounds on inhibition of transporters, bi-directional transport studies are performed in Caco-2 cells (American Type Cultur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent