BDBM106209 US9695174, 4

SMILES COc1ccc2c3C[C@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](C)NC4=O

InChI Key InChIKey=XDVXQQDQFWVCAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106209   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106209(US9695174, 4)
Affinity DataIC50: 610nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106209(US9695174, 4)
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:To determine potency of compounds on inhibition of transporters, bi-directional transport studies are performed in Caco-2 cells (American Type Cultur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
US Patent

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106209(US9695174, 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed