BDBM10824 3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-ethyl-N-methylcarbamate::Phenethylamine deriv. 53b

SMILES CCN(C)C(=O)Oc1cccc(CC(C)N(C)CC#C)c1

InChI Key InChIKey=YOOMCQRTUQTUJB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 10824   

TargetAmine oxidase [flavin-containing] B(Rat)
Teva Pharmaceutical Industries

LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 100nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 100nMAssay Description:Displacement of 14C-phenylethylamine from MAO-B (unknown origin) preincubated for 60 mins followed by substrate addition measured after 20 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Teva Pharmaceutical Industries

LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 120nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 120nMAssay Description:Displacement of 14C-5-hydroxytryptamine creatinine disulfate from MAO-A (unknown origin) preincubated for 60 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCarboxylic ester hydrolase(Horse)
Teva Pharmaceutical Industries

LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 1.50E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine as substrate preincubated for 60 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 2.34E+5nMAssay Description:Inhibition of human red blood cell AChE using acetylcholine as substrate preincubated for 60 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10824(3-{2-[methyl(prop-2-yn-1-yl)amino]propyl}phenyl N-...)
Affinity DataIC50: 2.34E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed