BDBM10921 3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-yl}oxy)propyl]amino}methyl)phenyl N-butylcarbamate hydrochloride::CHEMBL130918::aminoalkoxyheteroaryl deriv. 14

SMILES CCCCNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(c2)oc2ncccc2c3=O)c1

InChI Key InChIKey=ZYNRLEQFTJNNFH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 10921   

TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10921(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  8.90nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10921(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  24nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10921(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  4.23E+3nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10921(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10921(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed