BDBM111840 US8623906, JHE-02-032B::US9174969, JHE-02-032B

SMILES COc1cccc(NC(=O)N2CCc3cc(ccc23)S(=O)(=O)N2CCN(CC2)c2cccc(Cl)c2)c1

InChI Key InChIKey=OVOJOKTURLDQFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111840   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of South Florida

US Patent
LigandPNGBDBM111840(US8623906, JHE-02-032B | US9174969, JHE-02-032B)
Affinity DataIC50: 9.90E+3nMAssay Description:IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
University of South Florida

US Patent
LigandPNGBDBM111840(US8623906, JHE-02-032B | US9174969, JHE-02-032B)
Affinity DataIC50: 9.90E+3nMAssay Description:In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2014
Entry Details
US Patent