BDBM112461 US8623885, 2

SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(C)=O)nc12

InChI Key InChIKey=YJRPVMCKBPJNKR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112461   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Amgen

US Patent
LigandPNGBDBM112461(US8623885, 2)
Affinity DataIC50: 3.20nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Human)
Amgen

US Patent
LigandPNGBDBM112461(US8623885, 2)
Affinity DataIC50: 4.5nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent