BDBM112482 US8623885, 23

SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CCNCc4n3)nc12

InChI Key InChIKey=KIVUTDQWWQUQAK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112482   

TargetCyclin-dependent kinase 4(Human)
Amgen

US Patent
LigandPNGBDBM112482(US8623885, 23)
Affinity DataIC50: 8.60nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent