BDBM112502 US8623883, No. 8

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCC(F)C1

InChI Key InChIKey=XFXOYVZSTQCSQN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 112502   

TargetEpidermal growth factor receptor(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 45.3nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 212nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Warner-Lambert

US Patent
LigandPNGBDBM112502(US8623883, No. 8)
Affinity DataIC50: 234nMpH: 7.4 T: 2°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent