BDBM112598 US8618103, I-94

SMILES CC[C@@H](CO)Nc1ncc(c(N[C@H]2CCCN(C2)S(C)(=O)=O)n1)-c1cnc2[nH]ccc2n1

InChI Key InChIKey=MNLRALLJFYLNRI-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112598   

TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112598(US8618103, I-94)
Affinity DataKi:  0.00548nM IC50: 0.0110nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM112598(US8618103, I-94)
Affinity DataIC50: 0.0432nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
US Patent