BDBM1137 (4R,5R,6R)-Tetrahydro-5-hydroxy-3-[(1H-indazol-5-yl)methyl]-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone::(4R,5S,6R)-4-benzyl-5-hydroxy-1-(1H-indazol-5-ylmethyl)-6-(2-phenylethyl)-1,3-diazinan-2-one::Tetrahydropyrimidinone deriv. 87

SMILES O[C@H]1[C@@H](Cc2ccccc2)NC(=O)N(Cc2ccc3[nH]ncc3c2)[C@@H]1CCc1ccccc1

InChI Key InChIKey=ATLOVXNYEUHOMT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1137   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1137((4R,5S,6R)-4-benzyl-5-hydroxy-1-(1H-indazol-5-ylme...)
Affinity DataKi:  44nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1137((4R,5S,6R)-4-benzyl-5-hydroxy-1-(1H-indazol-5-ylme...)
Affinity DataKi:  44nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1137((4R,5S,6R)-4-benzyl-5-hydroxy-1-(1H-indazol-5-ylme...)
Affinity DataKi:  44nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1137((4R,5S,6R)-4-benzyl-5-hydroxy-1-(1H-indazol-5-ylme...)
Affinity DataKi:  44nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed