BDBM114620 1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(4-morpholinophenyl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 23

SMILES C=CC(=O)N1CC2(CC(c3nc(-c4ccc(C(=O)NCC(F)(F)F)c(OC)c4)c(-c4c(C)ccc5[nH]cnc45)n3C)C2)C1

InChI Key InChIKey=TZWKYFXHPWRBBT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 114620   

TargetGTPase KRas [G12C](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandChemical structure of BindingDB Monomer ID 114620BDBM114620(1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(4-morph...)
Affinity DataIC50: 5.50E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
US Patent