BDBM114625 1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(2-methylindazol-5-yl)imidazol-2-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one::US20260060961, Example 28

SMILES C=CC(=O)N1CC2(CC(c3nc(-c4ccc5nn(C)cc5c4)c(-c4cc(O)cc5ccccc45)n3C)C2)C1

InChI Key InChIKey=IFTCZPOPUMRCPB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 114625   

TargetGTPase KRas [G12C](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandChemical structure of BindingDB Monomer ID 114625BDBM114625(1-[6-[5-(3-hydroxy-1-naphthyl)-1-methyl-4-(2-methy...)
Affinity DataIC50: 1.00E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
US Patent