BDBM11551 (3R)-N-hydroxy-2-[(4-methoxy-1,1-biphenyl-4-yl)methyl]-1,2-thiazinane-3-carboxamide 1,1-dioxide::(3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methyl}-1,1-dioxo-1,2-thiazinane-3-carboxamide::CHEMBL103418::Sultam Hydroxamate 23a

SMILES COc1ccc(cc1)-c1ccc(CN2[C@H](CCCS2(=O)=O)C(=O)NO)cc1

InChI Key InChIKey=QVCXUWWKONKLBL-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 11551   

Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.400nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.900nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  1.20nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  938nM ΔG°:  -8.22kcal/molepH: 7.5 T: 2°CAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11551((3R)-N-hydroxy-2-{[4-(4-methoxyphenyl)phenyl]methy...)
Affinity DataKi:  938nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed