BDBM11553 (3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-hydroxy-1,2-thiazinane-3-carboxamide 1,1-dioxide::(3R)-2-{[4-(4-tert-butylphenyl)phenyl]methyl}-N-hydroxy-1,1-dioxo-1,2-thiazinane-3-carboxamide::Sultam Hydroxamate 23c

SMILES CC(C)(C)c1ccc(cc1)-c1ccc(CN2[C@H](CCCS2(=O)=O)C(=O)NO)cc1

InChI Key InChIKey=QAIMUZSIIGFZOG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 11553   

Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of MMP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.20nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi: <5nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCollagenase 3(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi: <5nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  8.5nMAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.17E+3nM ΔG°:  -7.50kcal/molepH: 7.5 T: 2°CAssay Description:The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM11553((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...)
Affinity DataKi:  3.17E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed