BDBM11696 (2S)-1-(2-{[2-oxo-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]amino}acetyl)pyrrolidine-2-carbonitrile::(2S)-Cyanopyrrolidine analogue 17::2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxo-ethyl]1,2,3,4-tetrahydroisoquinoline::CHEMBL371907

SMILES O=C(CNCC(=O)N1CCc2ccccc2C1)N1CCC[C@H]1C#N

InChI Key InChIKey=HGLYHGKGQIVSLQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11696   

TargetDipeptidyl peptidase 4(Human)
National Health Research Institutes

LigandPNGBDBM11696(2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylam...)
Affinity DataIC50: 3.24E+3nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
National Health Research Institutes

LigandPNGBDBM11696(2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylam...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human DPP4 expressed in baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
National Health Research Institutes

LigandPNGBDBM11696(2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylam...)
Affinity DataIC50: 4.17E+3nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
National Health Research Institutes

LigandPNGBDBM11696(2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylam...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2006
Entry Details Article
PubMed