BDBM117029 US8664236, A9::US9238651, A9

SMILES CN(c1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(C)c1)c1ccccc1F

InChI Key InChIKey=SMDRCKJLYKVNQP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 117029   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM117029(US8664236, A9 | US9238651, A9)
Affinity DataIC50: 9.70nMAssay Description:The compound inhibits the target protein in the enzymatic PDK1 inhibition assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM117029(US8664236, A9 | US9238651, A9)
Affinity DataIC50: 9.70nMT: 2°CAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1(Δ1-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM117029(US8664236, A9 | US9238651, A9)
Affinity DataIC50: 27nMpH: 8.0 T: 2°CAssay Description:The cellular assay for the determination of the PDK1 kinase activity is carried out as a Luminex assay in the 96-well format. PC3 cells are sown at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent