BDBM119748 US8680132, CB084- Isomer B

SMILES CC(C)(C)C[C@@H]1N[C@@H](C(=O)NC2CCC(O)CC2)[C@H](Cc2ccccc2)[C@]12C(=O)Nc1cc(Cl)ccc12

InChI Key InChIKey=LRJBXXRILYOKRP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 119748   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 119748BDBM119748(US8680132, CB084- Isomer B)
Affinity DataIC50: 5.00E+3nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was determined using an optimized, sensitive and quantitative fluorescence polarization-based (FP-based) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
US Patent