BDBM119751 US8680132, C04801

SMILES CC(C)(C)C[C@@H]1N(N(C(=O)C(F)(F)F)C2CC(C)(O)C2)[C@@H](C(=O)O)[C@H](c2cccc(F)c2F)C12C(=O)Nc1cc(Cl)c(F)cc12

InChI Key InChIKey=XIZIOVPHELHJAL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 119751   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 119751BDBM119751(US8680132, C04801)
Affinity DataIC50: 389nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 119751BDBM119751(US8680132, C04801)
Affinity DataIC50: 473nMpH: 7.5Assay Description:The binding affinity of the MDM2 inhibitors was optionally determined using a fluorescence polarization-based (FP-based) binding assay using a recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2014
Entry Details
US Patent