BDBM120388 US8703771, 1::US8703771, 12

SMILES CN1CCN(CC1)C1CCc2cc(ccc12)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1

InChI Key InChIKey=YTHUQGIGAIZNIM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 120388   

TargetTyrosine-protein kinase ABL1(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 5.80nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 53nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 256nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Harbin Gloria Pharmaceuticals

US Patent
LigandPNGBDBM120388(US8703771, 12 | US8703771, 1)
Affinity DataIC50: 2.25E+3nMpH: 7.5 T: 2°CAssay Description:The activity of the compounds of this invention on Abl, c-Kit and PDGFR kinases was tested by Mobility Shift Assay (MSA). Kinase buffer: 62.5 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent