BDBM120996 US8716285, 53

SMILES ONC(=O)c1ccc2NCC(Cc2c1)Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=YWYZSTJJOZEEKF-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 120996   

TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM120996(US8716285, 53)
Affinity DataIC50: 12nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM120996(US8716285, 53)
Affinity DataIC50: 470nMAssay Description:Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM120996(US8716285, 53)
Affinity DataIC50: 470nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM120996(US8716285, 53)
Affinity DataIC50: 9.96E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM120996(US8716285, 53)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed