BDBM124945 US8765972, 127

SMILES CC1N(C2CCN(CC2)C2CCCCC2)C(=O)c2c1cc(F)cc2C(N)=O

InChI Key InChIKey=JMSHIEXDPIOMCA-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 124945   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM124945(US8765972, 127)
Affinity DataKd:  60nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM124945(US8765972, 127)
Affinity DataKd:  60nMAssay Description:Displacement of fluorescent probe from human recombinant full length His-tagged PARP1 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM124945(US8765972, 127)
Affinity DataIC50: 640nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as reduction in H2O2-induced PAR formation incubated for 30 mins followed by H2O2 addition for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed