BDBM125014 Roche-Dataset for PDE10A, Compound 61::US8772510, 33

SMILES Cc1nc(C(=O)N2CCC2)c(C(=O)NCCc2nc(cn2C)-c2ccccc2)n1C

InChI Key InChIKey=KIUIEYBUNWSFHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 125014   

LigandPNGBDBM125014(US8772510, 33 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 86nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
US Patent

LigandPNGBDBM125014(US8772510, 33 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 86nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed