BDBM12644 (2S)-1-[2-(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile::CHEMBL96937::Cyanopyrrolidine 38

SMILES CC(C)(C)NCC(=O)N1CCC[C@H]1C#N

InChI Key InChIKey=DAQJYQUHXSBGJM-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12644   

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM12644(CHEMBL96937 | (2S)-1-[2-(tert-butylamino)acetyl]py...)
Affinity DataKi:  10nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM12644(CHEMBL96937 | (2S)-1-[2-(tert-butylamino)acetyl]py...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Abbott Laboratories

LigandPNGBDBM12644(CHEMBL96937 | (2S)-1-[2-(tert-butylamino)acetyl]py...)
Affinity DataKi:  3.30E+3nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Abbott Laboratories

LigandPNGBDBM12644(CHEMBL96937 | (2S)-1-[2-(tert-butylamino)acetyl]py...)
Affinity DataKi:  1.24E+4nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed