BDBM12645 (2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile::CHEMBL95089::Cyanopyrrolidine 39

SMILES O=C(CNC1CCCC1)N1CCC[C@H]1C#N

InChI Key InChIKey=QQNHTINEHANVJY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12645   

TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM12645((2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-c...)
Affinity DataKi:  11nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Abbott Laboratories

LigandPNGBDBM12645((2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-c...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Abbott Laboratories

LigandPNGBDBM12645((2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-c...)
Affinity DataKi:  293nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Abbott Laboratories

LigandPNGBDBM12645((2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-c...)
Affinity DataKi:  1.22E+3nMAssay Description:The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed