BDBM12720 6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 39b

SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3F)-c3ccccc3CN3CCCC3)c(=O)c12

InChI Key InChIKey=YNAITOPHNFDVOT-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 12720   

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM12720(6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phe...)
Affinity DataKi:  0.740nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM12720(6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phe...)
Affinity DataKi:  1.80E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb

LigandPNGBDBM12720(6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phe...)
Affinity DataKi: >2.50E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb

LigandPNGBDBM12720(6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phe...)
Affinity DataKi: >1.50E+4nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

LigandPNGBDBM12720(6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phe...)
Affinity DataKi: >1.50E+4nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2006
Entry Details Article
PubMed