BDBM134368 US8846658, 81

SMILES NC1=NC(COC1)(C(F)F)c1cc(NC(=O)c2ccc(Br)cn2)c(F)cc1F

InChI Key InChIKey=JFBAPCCCHNRWQY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 134368   

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM134368(US8846658, 81)
Affinity DataIC50: 300nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM134368(US8846658, 81)
Affinity DataIC50: 1.10E+3nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM134368(US8846658, 81)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain in presence of FRET substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed