BDBM135222 US8846657, 3.115::US8846657, 3.116::US8846657, 3.117

SMILES CO[C@H]1CCN(c2nc3cc(-c4noc(=O)[nH]4)nc(-c4cncc(Cl)c4)c3n2C[C@H]2CC[C@H](C)CC2)[C@H](C)C1

InChI Key InChIKey=RTDGVDRCLKUZIR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 135222   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 5nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 5nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 9nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 9nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 18nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 135222BDBM135222(US8846657, 3.117 | US8846657, 3.116 | US8846657, 3...)
Affinity DataIC50: 18nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2015
Entry Details
US Patent