BDBM136879 US10231967, Example 112::US8865911, 112::US9000182, 5, isomer 2::US9918985, Example 112

SMILES CO[C@H]1CC[C@@]2(Cc3ccc(cc3C22N=C(C)C(N)=N2)C#CC2CCC2)CC1

InChI Key InChIKey=HZHGVFUZMFVSNM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 136879   

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM136879(US8865911, 112 | US9000182, 5, isomer 2 | US102319...)
Affinity DataIC50: 2nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM136879(US8865911, 112 | US9000182, 5, isomer 2 | US102319...)
Affinity DataIC50: 22nMpH: 9.2Assay Description:The beta-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human beta-Secretase (AA 1-AA 460) was clo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2015
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM136879(US8865911, 112 | US9000182, 5, isomer 2 | US102319...)
Affinity DataIC50: 22nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetBeta-secretase 1 [1-460](Human)
Astrazeneca

US Patent
LigandPNGBDBM136879(US8865911, 112 | US9000182, 5, isomer 2 | US102319...)
Affinity DataIC50: 22nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Astrazeneca

US Patent
LigandPNGBDBM136879(US8865911, 112 | US9000182, 5, isomer 2 | US102319...)
Affinity DataIC50: 4.95E+3nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human (3-Secretase (AA 1-AA 460) was clone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
US Patent