BDBM14001 (6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapentacyclo[19.3.1.1^{3,6}.1^{15,19}.0^{9,13}]heptacosa-1(24),9,11,15(26),16,18,21(25),22-octaene-18-carbonitrile::Diastereomer A ( (R,R) or (S,R))::Diastereomer B ( (S,R) or (R,R))::Macrocyclic 3-Aminopyrrolidinone analog 26A::Macrocyclic 3-Aminopyrrolidinone analog 26B

SMILES O=C1[C@H]2CCN1C(c1ccccc1)c1cccc(Oc3cc(Cn4cncc4CN2)ccc3C#N)c1

InChI Key InChIKey=UEBNHTSMTQUOQB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14001   

LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 58nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 1.60E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50: 5.80E+3nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2007
Entry Details Article
PubMed