BDBM140984 US8916574, Compound 1

SMILES NS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=ZZKJYWJMKZJTKA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 140984   

TargetEpidermal growth factor receptor(Human)
Qilu Pharmaceutical

US Patent
LigandPNGBDBM140984(US8916574, Compound 1)
Affinity DataIC50: 2.71nMT: 2°CAssay Description:In vitro kinase analysis was performed by using HTScan EGF Receptor Kinase Assay Kit (#7909) and HTScan HER2/ErbB2 Kinase Assay Kit (#7058) from Cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Qilu Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM140984(US8916574, Compound 1)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of HER-2 (unknown origin) using poly-(Glu4-Tyr) as substrate after 1 hr by ELISA-based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Qilu Pharmaceutical

US Patent
LigandPNGBDBM140984(US8916574, Compound 1)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin) using poly-(Glu4-Tyr) as substrate after 1 hr by ELISA-based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed