BDBM140990 US10570123, Example 54::US8916576, 54

SMILES COCCNC(=O)COc1cccc(c1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1

InChI Key InChIKey=WBNSLYAHQGEHEX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 140990   

TargetRho-associated protein kinase 2(Human)
Surface Logix

US Patent
LigandPNGBDBM140990(US8916576, 54 | US10570123, Example 54)
Affinity DataIC50: 150nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Surface Logix

US Patent
LigandPNGBDBM140990(US8916576, 54 | US10570123, Example 54)
Affinity DataIC50: 150nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Surface Logix

US Patent
LigandPNGBDBM140990(US8916576, 54 | US10570123, Example 54)
Affinity DataIC50: 1.00E+4nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Surface Logix

US Patent
LigandPNGBDBM140990(US8916576, 54 | US10570123, Example 54)
Affinity DataIC50: 1.00E+4nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent