BDBM141373 US8916600, 7::US9738632, Example 8

SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)NC1CCCC1)c1ccc2OCCOc2c1

InChI Key InChIKey=RVPULAGDRCHQCB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 141373   

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141373(US8916600, 7 | US9738632, Example 8)
Affinity DataIC50: 0.796nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141373(US8916600, 7 | US9738632, Example 8)
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM141373(US8916600, 7 | US9738632, Example 8)
Affinity DataIC50: 1.30nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent