BDBM141390 US8921319, 12

SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1

InChI Key InChIKey=FYBDWVPJOGSTDV-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141390   

TargetPlasma kallikrein(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM141390(US8921319, 12)
Affinity DataKi:  18nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetPlasminogen(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM141390(US8921319, 12)
Affinity DataKi:  38nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetProthrombin(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM141390(US8921319, 12)
Affinity DataKi:  187nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

TargetCoagulation factor X(Human)
The Medicines Company (Leipzig)

US Patent
LigandPNGBDBM141390(US8921319, 12)
Affinity DataKi:  376nMpH: 8.0Assay Description:The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent